Boulder, CO
Full Time

Senior Scientist – Automation Specialist, High-Throughput Screening

Arpeggio is a drug discovery company using transcriptional fingerprints to understand differences between healthy and diseased cell-states in order to prioritize compounds for drug development. We are seeking an experienced scientist with expertise in design and implementation of high-throughput screening methods to further catalyze our drug screening capabilities. The ideal candidate should have experience in cell-based high-throughput drug screening using high throughput sequencing-based readouts. Additional experience with CRISPR screening and/or transcriptomics is preferred.

Job Responsibilities

The candidate will contribute to the development of novel methodologies designed to define transcriptional signatures reflective of biological activities. Once protocols are established, the candidate will be responsible for screening large chemical libraries in order to identify compounds capable of eliciting specific transcriptional signatures.

Salary: $80,000 - $120,000 a year

Job Requirements

  • BS/MS in molecular biology or biochemistry, 5+ years of experience in an industrial setting
  • PhD in molecular biology or biochemistry, 2+ years of experience in an industrial setting
  • A focus on automation of cell culture and/or library preparation
  • Extensive experience with liquid handling robots
  • Assay development experience focused on improving throughput in cell-based assays
  • Experience with RNA-based sequencing assays (i.e. RNA-seq, PRO-seq, GRO-seq)
  • Familiarity with statistical and computational analyses of HTS-based data is preferred, but not required

About Arpeggio Bio

Arpeggio combines nascent transcription data with machine learning to explore the activity of entire genomes, allowing an unprecedented view of disease states and responses to drugs.  We have partnered with many pharmaceutical companies since our founding in 2017, and are now focused on using our platform for the development of a series of small molecules for the treatment of advanced cancers.


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